The Story of Covid-19
Over the past several months, there have been many guesses about a new virus, Sars-Cov-2 (SC2). Research and some publications (academic, pre-prints, and blogs) have suggested various hypotheses. The prominent issue to be explained properly was the puzzle of hypoxia (lack of sufficient oxygen) that manifested in an unusual way: often the sick were still chatting away happily while their oxygen saturation dropped to dangerous lows. This later came to be known as happy hypoxics because with the level of hypoxia they showed, they should have been incomprehensible or unconscious, and not be walking and chatting with doctors or with friends on the phone. Yet they were and this was never seen before.
While most medical facilities rushed to judgment and labelled the hypoxia as ARDS and caused by pneumonia, the symptoms didn’t quite fit the diagnosis. Pneumonia usually starts as unilateral viral, taking on one of the lungs and not both. Later it may become bilateral as it turns to bacterial. However, regardless whether it is viral or bacterial, cough with heavy phlegm and sputum is strongly associated with pneumonia. Yet in the case of Covid-19, the cough is unproductive and dry. It is nothing like pneumonia.
ARDS seemed more on target with the symptoms, except for the big difference that in the case of ARDS, the patient is not talking, walking, happy hypoxic, but is barely conscious. So nothing we knew as a “disease” fit the bill as Covid-19 took hold. Ventilators clearly weren’t helping. Most patients on ventilators died–some hospitals reporting an astronomical, over 80%, death-rates of those placed on ventilators.
There were lots of discussions about hemoglobin and how the virus somehow takes hemoglobin out of the red blood cells; discussions about too many red blood cells plugging up the whole body and circulation, and other similar points of views. Then, all of a sudden some doctors discovered that many patients suffered blood clotting problems. This article still discusses lung problems and coagulation as two different problems. This article discusses the clotting in the lungs as pulmonary embolism, as if it were distinct from Covid-19. And here we can see the first signs of actual understanding. Indeed, when we talk about coagulation of the blood, we need to look at what is causing the blood clotting, where in the body, and how. Crucially, kidney failure was starting to become frequent and dialysis machines started to clog up with the platelets, which formed the blood clots. What was happening?
Endothelial Damage
Watch the video from MedCram, Covid-19 discussion from YouTube #75. This lecture summarizes a lot of knowledge (74 previous lectures) so if you are interested to learn more, sign up at medcram.com; it is free. Here is this lecture on MedCram itself. MedCram offers continuing education credits for doctors as well, so if you didn’t know it up until now, this is time for you to check it out.
Covid-19’s Connection to Metabolic Disease
I now understand why most people who die from Covid-19 have metabolic disease. Metabolic disease is a catch-all term that incorporates a number of health conditions associated with high levels of blood glucose and insulin. Before you think only of type 2 diabetes, I must call your attention to the following conditions, all encapsulated in the definition of metabolic disease: conditions that affect the breakdown of amino acids, carbohydrates, lipids, as well as mitochondrial diseases; basically any condition that affects the parts of the cells that produce the energy. In the case of Covid-19, we need to focus on one of these: carbohydrate metabolism. Why this is so will become clear later. The following are metabolic diseases that fall into this category of carbohydrate metabolism:
- Type 2 diabetes
- Insulin resistance
- Prediabetes
- Cardiovascular disease
- Stroke
- Cancer–not all but most
- Obesity–not all obese are metabolically ill but about 80% are
- TOFI (Thin Outside Fat Inside)
As hospital findings indicate, the most serious Covid-19 cases are presented by people who have one or more of the above underlying conditions. COPD and asthma are also on the underlying conditions list but later evaluations show fewer negative consequences. What is the connection of metabolic disease to Covid-19?
Covid-19 is an Endothelial Disease
The endothelium is a single-layer cell wall that lines the inside of every blood vessel.
The role of the endothelium is many fold, one of which is to protect the lumen (the area where the blood flows in the blood vessel) and also to permit certain substances through to the muscles. What muscles? The blood vessel itself. Few people realize that blood vessels are muscles. But you can envision it as a muscle, after all, if your drink caffeine, it is a vasoconstrictor, it constricts your blood vessels, and that’s only possible if the blood vessels are muscles. As muscles, blood vessels have many layers that ensure proper constriction or dilation when necessary, as well as food supply.
On top of the endothelium is a layer of hair-like substance (facing inward where the blood flows), which is the glycocalyx. It is a very slippery “hair” (cilia) that keeps the blood flowing in one direction. The blood flows in the lumen–inside the blood vessel lined with the endothelium and the glycocalyx. The glycocalyx is an essential protective layer that forms a barrier between whatever flows in the blood and the endothelial wall.
Glucose-Connection to Glycocalyx Damage
Glucose damages the glycocalyx, not only from long-term high carbohydrate consumption, but even from a single large glucose meal.
Eating lots of glucose in just one meal or in most meals, as in a typical American diet, means eating sugar and all sweetened foods, grains and starches (they are extremely high in glucose), most fruits, juices and soft drinks. This creates a large glucose load in the blood. Consumed just time to time or regularly with every meal, high-glucose-carbohydrates damage the glycocalyx–the glycocalyx can literally be destroyed. Most processed foods contain sugar, grains, and starches, so they also meet this category even if they are canned meat or vegetables.
Damaged Glycocalyx = Damaged Endothelial Cells
When the glycocalyx is damaged, all barriers to the endothelium are removed, allowing damage to the endothelium by anything in the blood, including pathogens, such as viruses. In this case, as the video from MedCram shows, SC2 viruses wee found in the endothelial cells. This then is the cause of the problem.
People with metabolic disease associated with carbohydrates have higher blood glucose levels than they should have, which damages the glycocalyx. These metabolic conditions are on the bullet-points above. Once the glycocalyx is damaged, it can take 8-12 hours for the glycocalyx to recover. So if one eats a carbs meal, such as a bowl of rice or beans, or a couple of slices of bread, or a pasta dish, or a slice of cake, or a glass of fruits juice or soda, or a large serving of tropical fruits, etc., that person causes an open vulnerable time period of 8-12 hours during which time SC2 virus can easily attack the endothelial cells.
For people with metabolic diseases, which come with high blood glucose, the glycocalyx is permanently damaged and damage to the endothelium is possible 24/7. To get a great understanding about the connection of the endothelium damage and clotting, watch this video. He doesn’t mention the glycocalyx, I suppose for the sake of simplicity.
The Clotting Factor
SC2 virus in the endothelial cells is bad news, because of the cascade of events that it initiates. Right below the endothelial cells at the layer between the endothelium and the muscle we find the von willebrand factor, which is on guard in case the endothelium is damaged, and it signals for clotting factors. The reason for this is clear: damaged endothelial wall can lead to excessive bleeding, so it is important to clot the damage as fast as possible. This is not any different from when you cut your finger.
Clotting factors, such as d-dimer, fibrin, prothrombin (see the video on clotting and endothelium above) and others (these are found in in Covid victims, usually in huge excess amounts) cause thrombosis (blood clots that are not in the main artery but anywhere else, including small blood vessels and capillaries) in the lungs capillaries and blood vessels, because the virus attacks the endothelial cells in the lungs, causing possible bleeding. Tons of capillaries in the lungs get thrombotic as a result of the endothelial damage. This is similar to pulmonary embolism (PE), except that whereas PE is one large blood clot, which can often be removed, in this case there are blood clots by the dozen or by the hundreds, in the capillaries of the lungs (I refer you back to the MedCram video on the top of the page for images on this). These tiny blood clots form tons of thromboses, preventing oxygenation. The lungs, as some other organs, try to find ways around the problem of closed-off capillaries by creating new capillaries. So the thromboses induce the growth of many new capillaries to bypass those plugged up with viscous blood. But there is scarcity of space in the lungs!
The Outcome
All through this, the lungs cannot exchange O2 and CO2 because the capillaries are closed off by thrombosis and as new capillaries form, the lungs “fill up” with these new capillaries. Ventilators don’t help because the problem is lack of blood vessels through which oxygen exchange could take place. So no matter how much the lungs are pressed in and out and filled with oxygen, while oxygen goes in and out of the lungs, it doesn’t go in and out of the blood of the patient. There is no oxygen movement in the blood. This is what leads to fatality.
PREVENTION
Prevention is likely possible. It is never too late to do your best to try to prevent a bad outcome. The most important thing appears to be the health of the glycocalyx to prevent the endothelium from damage and therefore the possibility of being attacked by the virus. To ensure that your glycocalyx is in great shape, make sure you keep your diet healthy and low in carbohydrates.
A healthy diet means different things to different people, and under normal circumstances we can just shrug our shoulders and accept our differences. However, if one thing Covid-19 has taught us, it is that metabolic health means a lot more than long-term-managed type 2 diabetes or the loss of excess weight. Metabolic diseases associated with carbohydrates are preventable. Those that are already established are possible to reverse and very advanced forms are possible to put to remission. Learn how to reverse metabolic disease by the ketogenic diet here.
To reduce or prevent damage to the glycocalyx and thereby to the endothelium, we must stop eating excess carbs! We most certainly must stop eating sugar, grain, starch, fruits that are naturally high in sugar, fruit juices (even from the fresh fruit picked from our own trees), soft drinks, and processed foods.
It is unclear to me how much damage industrially processed vegetable and seed oils may cause to the glycocalyx. From similar endothelium damage occurring in cardiovascular heart diseases leading to heart attacks, we know that processed oils are highly oxidized rancid oils that cause damage to the artery walls. Since they are damaging to the endothelium, likely they cause damage to the glycocalyx as well. This means we must stop all processed foods because they always contain some form of sugar and are made with these bad oils.
There has never ever been a better time to start on a low carbohydrate diet!
My Thoughts
This terrible disease will most certainly be still throwing some curve balls at us as time passes. I will keep on updating as time allows. This should provide enough coverage and understanding to help you see what you need to do to improve your chances in case you catch the bug. You have a chance to come out alive.
Comments, as always, are welcome and are moderated for appropriateness
Angela
Clueless Doctors & Scientists 
I am sure Dr Stanton must know Jason Fung. He just posted this video, but he did not mention how fasting probably helps maintain healthy glycocalyx. Likely a contributing factor to better covid results.
How Intermittent Fasting Boosts Immunity | Jason Fung
5,743 views, Aug 28, 2022
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Thanks Vincent,
I am familiar with him and also his fasting regime and all. His fasting is suggested primarily for weight loss.
Dr. Longo et all have shown (see The Science of Fasting–I think 10 years old film and many articles, of course) that fasting initiates the immune system’s growth and strengthening. It is very well understood.
Had you been a member of my Facebook migraine group, you would have read over 2 years ago that I was already recommending everyone to fast when they are sick with Covid and even before it time to time for protection. I fasted through my 3rd Covid. The second I had was asymptomatic and was caught by accident, and the first one was at the very start in January 2020 when we had barely known anything about Covid except for the Seattle nursing home and the Princess Diamond at sea.
Below I copy-paste my memos to my migraineurs in descending order, since I made updates several times over the 3 years. Here I am starting with the most recent and heading down toward the first update in March of 2020. Note the TRE and fasting recommendation all through:
Covid Update on Omicron: 2-14-2022
A short update on what to do if you catch Covid now–chances of you catching Omicron variant is almost 100% at this point.
You can catch Covid even if you are vaccinated–I had triple dose with booster and still caught it. The vaccine wont prevent you from catching it but your immune system will be ready for it and you will respond very fast. Mild symptoms if you were vaccinated, and fast recovery.
–If you haven’t been vaccinated, worldwide the number of dead have sharply increased, but in terms of percent of dead relative to those who have caught it is fewer. So death rates have dropped but you see more dead. Omicron is still deadly if you have autoimmune conditions or comorbidities.
–If you catch cold, tummy symptoms, fatigue, chills, fever/no fever, sore muscles, nausea, pelase consider the possibility that it is Covid and get tested within 5 days from the start of symptoms.
–If you test positive: as long as you are positive, cut all carbs out of your diet–even milk. Covid is a vascular virus but it can only attack if you damaged your glycocalyx, a protective layer of your blood vessels wall inside. The glycocalyx get damaged/destroyed by high blood glucose! Avoid all carbs–plant and animal form. Stick with no carbs till the point you test negative.
–Don’t take any medications! Medications reduce your symptoms, such as fever, for example, but fever kills the virus, so reducing the fever lengthens your illness! The discomfort you feel is NOT the virus but your immune system. You don’t want to weaken your immune system. So don’t medicate. The stuff definitely hurts! But only for a few days if you follow this guidance.
–Don’t add carbs back unless you tested negative for the virus.
–The 8th day rule: This is developed by Dr. Shankara Chetty in South Africa. He found that Omicron recovers by day 7 for most people and they are all well. However, many start feeling sick again on day 8! His hypothesis is that this is an allergic response to the spike protein fragments in the body. He gives his patients antihistamines. I ended up sick on the 8th day, and took Zyrtec–a whole body antihistamine that didn’t make me sleepy and voila, all is well! It works!
I hope everyone will recover from Covid fast. One can also catch in more than once, I caught it twice. If your partner and you both are vaccinated, it is possible that the sick doesn’t pass on the bug! My hubby never caught it from me, even though we shared even the same spoon eating stuff! So vaccines do protect!
Stay safe and keep other safe!
Delta variant guides September 2021:
Update on Covid: Delta variant behaves differently from others. I have been hearing from several members that they or some family member or friend has caught it and what should the protocol be. Since the Delta variant behaves very differently from the original one, it may be a good time to rehash what the ideal thing to do would be to help yourself and loved ones.
If you feel sore throat, scratchy throat, nausea, fatigue, fever, symptoms of cold with lots of sneezing, etc., consider that it may be Covid and get tested right away! The virus only stays in the body for up to 5 days past first symptoms, so if you delay, you may miss the proper diagnosis.
–Be sure to notify your doctor! There are several reasons for this. First, if you are positive, it can go on your record, so if you get complications they will know what to do. Notification is also important so that you can have access to immediate help if you need it.
–Notify all people you can with whom you came in contact for up to 3 weeks prior to your diagnosis. The virus can be in your for up to 3 weeks without you knowing and this is the time when you were very infectious!
–Don’t panic! If you are metabolically healthy, have no autoimmune diseases, and if you were vaccinated, the illness will likely be mild.
–It is important to understand that Covid is not a respiratory bug like the cold, even if the symptoms are the same. It is a vascular disease and it causes mini blood clots in the organs it touches. The long-Covid refers to the time period the body takes to heal from these blood clots (thrombi). So if you feel terribly fatigued, it is your heart that is affected, if you are coughing, it is your lungs, if you feel nauseous it may be the pancreas, liver, or kidneys.
–What to do: relax, cook several batches of bone broth (just bone, water, salt), and if you can stop eating, stop! Not eating for 2 days renews your immune system, providing you with a boost of healing. If you must eat, eat carnivore (ZC) and no dairy. Absolutely avoid all carbs–including veggies and fruits as well while you are ill. The virus attacks the endothelial wall and goes through it, but it can only do so if it is weakened. The endothelial wall is weakened by carbs!
–Your doctor may prescribe steroids and other medications to help you. If your lung is the one attacked, you may benefit from NAC but ask your doctor first! It may interact with other meds you may be taking. NAC only helps lung-version of the disease.
You can take vitamin C and D3 to boost your immune system and check your LDL by blood. The LDL carries all fat-soluble vitamins. Report if your LDL count drops please.
Good luck everyone! ❤
Covid Update 1/1/2021
Symptoms of Covid:
Symptoms can be anything from sore throat, loss of taste or smell, vomiting, diarrhea, rashes, fatigue, headache, or no symptoms at all!
It is important that you understand that Covid need not have any symptoms and people can just collapse and end up unconscious and even dead! This just happened to a friend of mine! I also just read this happening on a plane, where the person actually died by the time the plane landed. The person tested negative (one need not test positive to Covid to have Covid) and had no symptoms but collapsed on the plane and then died after landing.
This is a quick summary for those of you coming down with Covid on what to do and what not to do:
Covid is a vascular disease and not a respiratory one, so don’t treat it like a cold or a flu even if your symptoms are that of a cold or the flu!
To learn about the vascular nature of Covid, please read this article: https://cluelessdoctors.com/…/25/covid-19-from-up-close/
Don’t eat/drink carbs when you have Covid. Carbohydrates increase damage to your system and causes a bigger immune response
Fast if you can. If you are hungry; eat the carnivore diet through your illness. Absolutely no carbs please, not even milk. Fasting 16 hours can help you rebuild the glycocalyx destroyed by carbs, and that can prevent your body from releasing clotting factors, causing “thrombi” (mini blood clots), which then drive the ground glass opacity lung damage, heart damage, brain damage, liver and kidney failure. This is essentially the most important part of your treatment: prevent the release of blood clotting factors!
Take supplements: 1000 mg C every wake hour if you can, without food. Liposomal C is fine if you get upset stomach from that much Ascorbic Acid. Take B1 (TTFD type) with C, at least once a day; this protects against C converting to oxalates. Take 1200 mg NAC total a day (400 mg capsules 3 times a day or time release 600 mg twice a day), which is not a vitamin but is an antioxidant precursor (it converts to Glutathione). Take 6000 IU D3 (use Health by Principle type, which has magnesium and is in coconut (MCT) oil). Also continue to take magnesium, B2, and any other vitamins/supplements you were taking before.
As long as the virus is still in your mouth, nose, throat, sucking on slow dissolve zinc lozenges may help deactivate a large load of virus. It can do so only by contact, so once the virus is in your lungs, zinc will no longer help without a zinc ionophore. Supposedly Quercetin is a zinc ionophore but its unproven. A proven zinc ionophore is hydroxychloroquine. If you take zinc lozenges, take it several times for an active infection for only max 3 days.
I don’t recommend the taking of melatonin, because it is a hormone that regulates circadian rhythm, and by its hormonal nature, once you started taking it, your body will adapt and pending age and other variables, you may need to take it for life. Melatonin is not an antioxidant… it is merely a sleep cycle regulator.
I don’t recommend taking glutathione (gets destroyed in the stomach), elderberry (plant-based antioxidant, which works for plants but we are not a plant, plus it’s carbs), herbs, and other vitamins.
Invest in a pulse oximeter to ensure your oxygen level remains high enough. Many people don’t feel low in oxygen before they pass out… this is a very typical problem and is dubbed “happy hypoxics”. It’s better to be safe than sorry. A cheap pulse oximeter will do. If your O2 saturation drops to 90% please head to the emergency. If it is in the 80s, call the ambulance.
I hope everyone will recover very fast! ❤
Covid-19 update 7-31-2020
While by now we all hoped to not have Covid-19 discussions, it seems necessary to continue our vigilance and also keep our knowledge up to date on what is happening and clear the fake information from that of real information, and the potential good from the definitely or potentially harmful. So here is my update, which contains all of what I know, only in brief lay language:
The virus is now, in some ways, a bigger threat then before. One reason for this is that we are all tired of it and wish to not even think of it. But we need to remain on alert.
Another is point 2)
–The virus is mutating. In one article I read that it has 6000 different mutations, in another I read 6 main different mutations. It’s not possible for me to test which is right but the 6 sounds completely reasonable. This means that different mutants will have different symptoms and may cause completely different diseases. So keep on alert.
–The virus spread by vapor (from breath, talk, not just sneeze and cough) more than from touch. This doesn’t mean you don’t need to wash your hands! Keep on washing it. But it DOES mean you need to wear a mask.
–Masks are not 100% protection but if each person wears a mask, the transmission probability is exponentially reduced. So if my masks protects 50% and yours also 50% than we both are 75% protected! Keep that in mind. if everyone wears a mask, we can literally cut the probability of catching the bug to close to zero.
–Covid-19 is not a respiratory disease but an endothelial disease. As such, the prevention is keeping you endothelial cells healthy: aka eat low carbs, be metabolically healthy, be sure your fasting blood glucose is in the range of 70-99 and not over 110 for sure!
–While there is lots of work toward vaccine, most people lose immunity to Covid shortly after they recovered! This makes vaccine difficult (need to be RNA vaccine) and past infections–at this time–don’t guarantee protection from a second infection of same
Prevention is less clear but here are the things of importance:
–low carbs or no carbs, and fast if you come down with it
–make sure your vitamin D level is in the top 70-80% of the max. If not, supplement, If higher, stop! Higher than normal (toxicity) is harmful so don’t go there
–vitamin A — again, you need to have a blood test. If you are OK, don’t supplement. Vitamin A can harm the liver.
–vitamin C–there is no guideline on how much, but B1 (choose the kind we use) is essential to prevent C from causing kidney stones! I take C capsule now where each is 550 mg and I take 2 at the time, several times a day–but I have some breathing problems that you don’t. In any case, I take 1 Allithiamine (50 mg) per 550 mg C.
–NAC–this is recommended if you catch the bug. It is not going to help you preventively. Max dose 1200 mg a day. I recommend 400 mg 3 times or 600 mg twice.
–zinc lozenges after being exposed by shopping, etc. Watch dose since this can cause problems with copper
–quercetin–some doctors recommend quercetin because it is a zinc ionophone. I have not found support for this in literature, so it is up to you
DO NOT TAKE any herbs or elderberry, etc.
Be sure you are always hydrated properly! Don’t leave home without mask(s) and water with salt!!!
3-24-2020 Update
Additional information about symptoms and treatments of Covid-19.
There is quite a bit of variability in symptoms, but here are the latest from a variety of news sources from the TV as well as healthcare practitioner resources:
–about 30% of those with Cov-19 lose their ability to smell and taste. This is similar to how some people also feel that way just from a common cold.
–about 50% of those with Cov-19 get some form of GI disturbance. Some vomit, explosive diarrhea was also mentioned
–not all people cough because many have minimal or no symptoms. There are no percentages given since there is no way to figure out how many people have asymptomatic infection
–not all people have fever, and of those who do, some get very high fever, others get low fever, some for several days, others for just a day or so, and many not at all, because there is no way to figure out how many people have asymptomatic infection
–it seems that most people feel their lungs becoming smaller and in a torture chamber at some level–this can be minor for just a couple of days, or minor for weeks on end, or very serious, and also fatal. Again, there is no way to estimate percentages because there is no way to figure out how many people have asymptomatic infection
–it seems most people feel tired like a truck went over them for at least one day.
So far the best at-home treatments that are a must:
–sip hot lightly salted water all day long–this doesn’t add into our water amount but be sure to calculate salt. Place about half the regular salt amount into your water for this.
–have your humidifier set up in your room. Moist air keeps your mucus moist
–don’t take fever reducers unless your doctor tells you past 103F (39.44C). If you reached 103F in temperature, call the CDC hotline for Cov-19 testing local to you. You can also call your local hospital or ER. Don’t call your doctor. Chances of your doctor being able to test for the virus is zero. Be sure to call ahead to alert the ER that you suspect Covid-19 so they don’t pack you into the waiting room for 5 hours with 200 people.
–Practice TRE each day as long as you can–16 or 18 hours of not eating are ideal. Do drink salt and water
–It is now understood that this virus removes potassium from the blood like there is no tomorrow. A study showed that patients needed potassium infusion of 42 gr (that’s 42,000 mg, which is 52.5 times the dose a cardiac patient gets in the US for emergency! Please don’t try this at home.
However, if you see your body swelling, and you can also measure your weight on the scale and if it is increasing, please eat a high-potassium food (salmon, steak, avocado) WITHOUT salt.
Cheers,
Angela
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An interesting and enlightening article. Thank you…
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Thanks Andres.
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study dr robert cathcart and vitamin c. Zinc 100-200 mg a day under corona plus C as Cathcart tells us.
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What does this have to do with this article though? This is not about what some people may use to prevent or reduce the effect, but an explanation of what the disease is.
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Thanks for this, I wondered how this process works with those (1 in 10 people to be precise) who have been affected by covid symptoms on a long term basis I.e 3-4+ months. When oxygen levels are reading at 100% and vitals mostly all normal so they’re not quite classed as ill enough to be admitted to hospital in the majority of cases. If the oxygen levels are all normal, it’s a mine field.
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Mia most people don’t have 100% Oxygen Saturation even when fully healthy. There is also an age variant to this–the older one gets, the lower oxygen saturation is considered to be within normal ranges. An oxygen saturation over 90% is considered normal for all age groups. Below 90% there are variants.
In this article I refer to happy hypoxics whose oxygen saturation may be as low at 50% and are still happily chatting on their phones. It refers to that sort of an oxygen saturation and not light drop. They have mostly normal vitals but their oxygen saturation is very low. So the only sign of trouble is the low O2 SAT.
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Shared this immediately on my FB page 😈
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Thanks Roald! 🙂 Hope you are staying healthy!! ❤
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