Migraine Prodromes! You Think You Know Everything! Do You?


My latest academic journal article is published (pre-pub status). It defines what prodromes mean to migraines. In general academic literature, prior to my publication, prodromes simply precede migraines but for no apparent reason. The only exception is aura migraine that seems to be better understood. However, other prodromes are not understood and several prodromes are completely unknown by the scientific community.

In my latest academic journal published article Functional Prodrome in Migraines I redefine prodromes by showing their functions and purpose. My understanding of their functions comes from working with thousands of migraineurs in a Facebook group. While the group’s purpose for the migraineur members is to learn how to become migraine free, their talk with me helped my understanding greatly of the various prodrome types and what those prodromes mean. Many very important prodromes that migraineurs have are completely unknown to the scientific community. I suppose it takes a migraineur to understand what questions to ask and though I am a scientist, I am also a migraineur. That certainly helps!

Understanding what kind of prodromes other migraineurs had in addition to the kinds I had (migraineurs are pretty much alike–all migraineurs seem to be siblings in more ways than one!) in turn helped me identify the best migraine prevention methods without the use of any medicines. A couple of previous academic journal articles I published explain various elements of migraine.

One of my academic journal articles explains Migraine Cause and Treatment with some revolutionary details based on scientific understanding of the cell and what it needs for energy to be able to function in a migraine brain. Migraine brain is anatomically very different from the brain of a non-migraineur.

Another academic journal article of mine is connected to migraines but it is primarily a critique of how statistics is used. Cardiology is its main avenue to bring the problems to the surface. It discusses the problems of statistics used in the connection of increased dietary salt and the “related” blood pressure increase: Are Statistics Misleading Sodium Reduction Benefits? This article is very critical of nearly all research publications associated with salt and its connection to blood pressure. It is amazing to see how many scientists don’t fully understand the statistic results they receive and jump into conclusions that are completely erroneous.

I hope you enjoy reading all three of my academic articles (the language I kept is simpler than typical academic papers full of acronyms and jargon) and learn more about migraines. Then visit my Stanton Migraine Protocol® website and read the many testimonials.

Migraine is not a disease but a condition representing a brain in energy crisis. No amount of medicines will solve the problem of an energy crisis but understanding what energy crisis means will help us knowing how to fix it. Proper energy provided the right way aborts and prevents all migraines without any medicines. The goal is to learn to recognize migraines prior to their start. Few migraineurs know how to recognize functional prodromes before migraine starts without training.

Please read all three articles and contact me with any questions you have.

Comments are welcome!


About Angela A Stanton, Ph.D.

Angela A Stanton, PhD, is a Neuroeconomist focusing on chronic pain--migraine in particular--physiology, electrolyte homeostasis, nutrition, and genetics. She lives in Southern California. Her current research is focused on migraine cause, prevention, and treatment without the use of medicine. As a forever migraineur from childhood, her discovery was helped by experimenting on herself. She found the cause of migraine to be at the ionic level, associated with disruption of the electrolyte homeostasis, resulting from genetic variations of all voltage dependent channels, gates, and pumps (chanelopathy) that modulate electrolyte mineral density and voltage in the brain. In addition, insulin and glucose transporters, and several other variants, such as MTHFR variants of B vitamin methylation process and many others are different in the case of a migraineur from the general population. Migraineurs are glucose sensitive (carbohydrate intolerant) and should avoid eating carbs as much as possible. She is working on her hypothesis that migraine is a metabolic disease. As a result of the success of the first edition of her book and her helping over 5000 migraineurs successfully prevent their migraines world wide, all ages and both genders, and all types of migraines, she published the 2nd (extended) edition of her migraine book "Fighting The Migraine Epidemic: Complete Guide: How To Treat & Prevent Migraines Without Medications". The 2nd edition is the “holy grail” of migraine cause, development, and prevention, incorporating all there is to know. It includes a long section for medical and research professionals. The book is full of academic citations (over 800) to authenticate the statements she makes to make it easy to follow up by those interested and to spark further research interest. It is a "Complete Guide", published on September 29, 2017. Dr. Stanton received her BSc at UCLA in Mathematics, MBA at UCR, MS in Management Science and Engineering at Stanford University, PhD in Economics with dissertation in neuroscience (culminating in Neuroeconomics) at Claremont Graduate University, fMRI certification at Harvard University Medical School at the Martinos Center for Neuroimaging for experimenting with neurotransmitters on human volunteers, certification in LCHF/ketogenic diet from NN (Nutrition Network), certification in physiology (UPEN via Coursea), Nutrition (Harvard Shool of Public Health) and functional medicine studies. Dr. Stanton is an avid sports fan, currently power weight lifting and kickboxing. For relaxation (yeah.. about a half minute each day), she paints and photographs and loves to spend time with her family of husband of 45 years, 2 sons and their wives, and 2 granddaughters. Follow her on Twitter at: @MigraineBook, LinkedIn at https://www.linkedin.com/in/angelaastantonphd/ and facebook at https://www.facebook.com/DrAngelaAStanton/
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9 Responses to Migraine Prodromes! You Think You Know Everything! Do You?

  1. Roald Michel says:

    I’ve read all 3 articles you mentioned above. Great stuff.

    From one of them:

    “Both can be considered limitations to our findings.”

    Although you’re probably right, I think you’re too modest (or like to appear so :D). Why is that? Because…….

    “……we encouraged each recovering migraineur to enjoy a sugary candy or dessert after they were fully migraine free. This caused a migraine in every single participant without exception.”

    And the icing on the cake?

    “The administration of a 1/8th teaspoon salt after consuming the sweets with only a sip of water stopped the migraine within 10 minutes.”

    That’s enough for me to generalize the findings, and forget about the “limitations”.

    Liked by 1 person

    • Be Healthy says:

      I agree Roald. Unfortunately, I really have no choice in the matter because the findings are not based on what academia and the medical research community wants to see: clinical trial.

      One of the 3 papers I submitted to JAMA (the first one, Migraine Cause and Treatment) and the editor’s response was “very interesting and we would consider it but do you have a clinical trial?” (not an exact quote only something similar to what he wrote back…)

      At the same time journals publish clinical trials after clinical trials plagued with errors but that is OK. In fact, one of my 3 papers (Are Statistics Misleading Sodium Reduction Benefits?) examines the entire class of clinical trials about the increase of BP when dietary salt is increased. All research was done wrong: they ignore major contributing factors to BP that magnify changes–including the change in BP as a result of the mere mention of the possibility that salt was increased. I can see the BP increasing for people who are only thinking about eating more salt in my migraine group! It is so chiseled into people’s minds that salt is bad for them that they show up with a BP increase after eating a dash of extra salt on their meal. What does that have to do with BP increasing as a result of dietary salt increase? Not to mention that the change in BP is so tiny as to not even worthy a mention particularly since the normal daily variations in BP are 39 mm Hg (110 – 139 is systolic is totally accepted movement during the day).

      And yet, with all these errors, they get published because they are “clinical trials.” The whole academic publishing is messed up because the editors are trying to play it safe even if they are wrong. Einstein’s paper on the Theory of General Relativity would NEVER be published today. I am just writing about this in the 2nd edition of my book. There are 2 types of accepted work today: evidence based or scientific research based. I actually make fun of evidence based because of how it is defined and here I quote from my book to be:

      “Evidence based medicine is defined as

      “the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients” (140). Obviously, anything “current” best evidence about what migraine is and how to treat it would lead to dead end. In other words, evidence based would not be able to apply anything new since it has not yet been evidenced. This is quite a contradiction and many scientists make fun of it—I happen to be one of them. I take it a step further and apply a rule of business management to show its impossible “premise” via a well understood business principle. There is a saying in business management that a mission statement that can be rendered useless by negating the statement (by reversing a word of “yes” to “no” or its meaning), if the statement loses its value it has no meaning. So let’s try this by applying this rule to the definition of evidence based medicine: “the conscientious, explicit, and judicious use of current [worst] evidence in making decisions about the care of individual patients” (ouch) or “the [not] conscientious, [not] explicit, and [not] judicious use of current best evidence in making decisions about the care of individual patients” (bigger ouch) or “the conscientious, explicit, and judicious use of [not] current best evidence in making decisions about the care of individual patients” (heh… fun times). As you can see, in any form, applying the rule of a proper mission statement, evidence based medicine approach fails.”

      For evidence based research the sun is still rotating around the earth…

      On the other hand, scientific research based medicine is one that does its best to negate a theory, try to overturn it, and then repeat it many times. There is nothing about the mission statement of science based research that could be turned around to make it become ridiculous. It is a sound statement working on “what can be” and not “what they said it was”; note the words “clinical trial” are not actually part of it. So modern day academic medicinal publishing is evidence based and thus we are not moving ahead in any way. I should write a paper about this. 😉 And although my research has done all of what science based research has asked for, including the repeatability over thousands of times with the exact same outcome, it is not accepted for publish in “better” journals because it is not based on clinical trials. I would like them to recall that the biggest discoveries are never based on clinical trials or anything that is already an evidence. Clinical trials are the dots at the end of a sentence based on evidence.

      But I am just a little scientist barking up a very tall tree so it is pointless.

      Many doctors actually agree with you. I had a client tell me that her neurologist wrote a list of possibilities for her to evaluate for her migraines’ treatment and one of them was the Stanton Migraine Protocol®… A local hospital is referring migraine patients to me as well because nothing they do can help migraines–need I say that of course, all of what they do were published and were based on clinical trials and are evidence based… lol… and none works!

      Mine works but is not a clinical trial–it cannot be a clinical trial. You cannot lock people up (the generation who has the most migraines) for a month and put them under strict lifestyle change! The medical research community is clueless. I am glad I was able to publish at all and was totally shocked when 3 reviewers all loved my papers and wanted only minor changes even if the papers they are published are not top tier journals (yet).

      I am also glad that over 4000 people are migraine free (can prevent their migraines completely) without the use of any medicines by simply using the Stanton Migraine Protocol®. The rest? I could care less about. I am not after the Nobel Prize but surely want to get the term “migraine is a neurological disease” removed from medical dictionaries! And for heaven’s sake, stop putting migraineurs on those horrible medicines when a little bit of understanding can do magic in prevention! ❤


      • Roald Michel says:

        Already as a student I more than once told my teachers (um….professors) that they erroneously handled the data gathered from their research projects, and what they presented to “the public” was more or less identical to what a crooked salesman does, e.g. showing a graph/chart in such a way (tampering with the x and y axis) that it confirms what they are saying, whether it’s true or not.

        Positive peer reviews often are plagued by “if you scratch my back, I’ll scratch yours”, rendering them worthless.

        “Evidence based” raises many red flags in my house as well as my bullshit meters go on strike.

        The time Ignaz Semmelweis suggested antiseptic procedures, members of the medical establishment laughed at him hysterically, yelling: “Hahahaha, they’re dying from stuff we can’t see? Hahahaha”.

        Yeah, it never varies. And there is one reason more for that…….. “Mundus vult decipi, ergo decipiatur.” 😀

        Liked by 1 person

      • Maddy says:

        I suspect the response you received from JAMA beyond the typical Ivory Tower psychosis, has to do with what I observe as our MD’s being largely trained by the pharmaceutical industry on some level. They are trained to diagnose symptoms so as to prescribe the correct prescription pharmaceutical, root cause not necessary pursued. As you noted few stay up to date with research, and right now with genetic, epigenetic and the sheer power of laboratory equipment these days the research is moving ahead very rapidly. I recently saw an endocrinologist at a leading NYC institution, asked about a non-prescription supplement which is known widely in research to be a secondary insulin signaling compound, research in the 90’s, and she looked at me blank stare.

        Liked by 1 person

        • Be Healthy says:

          Oh Maddy thanks for the Friday morning laugh on your “blank state” comment. I suspect you were asking about cinnamon or Jicama or is there some specific compound of these and more?

          You are totally correct, by the way, on the influence of pharmaceuticals on everything health related. Pharmaceutical, medical providers and insurance companies manage disease-care; I no longer call it healthcare since it is not true. The healthy need no care. I also understand that the ill, once they discover the power of self care and the cause of their illness, will not need any medicines. Then the pharmaceuticals will seriously be financially hurt so it is not in anyone’s interest to provided non-medicinal care. I find little hubs pop up here and there fighting certain aspects of medicine free care that I suspect may be connected to one of these groups in some way.

          Migraine is one of those cases where medicines are clearly not needed at all but most doctors (not all luckily by now!) still only prescribe medicines. For my biggest surprise, some actually start to recommend my protocol, which is amazing.

          By the way, if you have T2D, you may want to read the book “Wheat Belly Total Health” by William Davis. I have several friends with T2D and several I reversed already by applying the knowledge of that book with some modification of the diet, combined with the Stanton Migraine Protocol®. It requires dedication and commitment on the part of the patient and it is not easy to do because one must give up a few favorite dishes but total cure is possible without any medicines or supplements.

          I tend to look at things from the perspective of the metabolic processes of individual cells in our bodies. What I see there is very different from what doctors see and that is why migraines respond extremely well to the Stanton Migraine Protocol® without taking any medicines or supplements. High blood pressure and diabetes also responds extremely well as does IBS, anxiety and depression. Apparently these all have the same basic cause at the cellular level. 🙂

          One day everyone with these “diseases” (not even diseases!) will be medicine free and healthy (as they are even now only with a mismanaged diet) and without pain!



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