New Journal Article Published on Migraine


An article I wrote is in “Article in press” mode publishing on December 1st. Title “Migraine Cause and Treatment” in the Journal of Mental Health in Family Medicine.


Migraine Cause and Treatment

Background: Research shows that migraine brains have hyperactive sensory organs and multiple sensory receptor connections. Hyper activity of these organs needs extra supply of nutrition to support increased electrical activity. Today’s medicines reduce or prevent the functioning of these neurons by blocking essential voltage dependent calcium or sodium channel instead of providing nutrients. We asked: if we provide support for extra electrical activity of migraineurs, would it prevent migraines without the use of medicines?

Methods: We reviewed published literature and conducted research over 6 months studying 650 volunteer migraineurs in a migraine-research Facebook group. Participants were screened for migraine types, answered a questionnaire on medical conditions, medicines used, and lifestyle. They were provided instructions on the use of the migraine protocol and were evaluated weekly.

Findings: Migraine frequency appears to be exacerbated by carbohydrate-rich and salt- and water-poor diets and may be worsened by medicines that block voltage gated calcium or sodium channels. Stopping these medicines, reducing carbohydrates and increasing saline in electrolytes appears to prevent and/or stop migraines.

Conclusions: H2O and Na+ efflux from cells caused by glucose, electrolyte mineral (Na+, Cl, K+) ratio may be disrupted in carbohydrate heavy diets causing migraines. Changes to diet that include increased salt intake along with reduced carbohydrate intake appears to prevent glucose induced electrolyte changes which then decreases migraine frequency. In the present study, all participants who made these dietary changes were able to eliminate migraine medications and remained migraine free.

Enjoy reading the full article! I hope to elicit more than usual turmoil since this article goes against all conventional migraine treatments but it actually works and there are no medicines involved. 🙂

Comments are welcome as always!


About Angela A Stanton, Ph.D.

Angela A Stanton, PhD, is a Neuroeconomist focusing on chronic pain--migraine in particular--physiology, electrolyte homeostasis, nutrition, and genetics. She lives in Southern California. Her current research is focused on migraine cause, prevention, and treatment without the use of medicine. As a forever migraineur from childhood, her discovery was helped by experimenting on herself. She found the cause of migraine to be at the ionic level, associated with disruption of the electrolyte homeostasis, resulting from genetic variations of all voltage dependent channels, gates, and pumps (chanelopathy) that modulate electrolyte mineral density and voltage in the brain. In addition, insulin and glucose transporters, and several other variants, such as MTHFR variants of B vitamin methylation process and many others are different in the case of a migraineur from the general population. Migraineurs are glucose sensitive (carbohydrate intolerant) and should avoid eating carbs as much as possible. She is working on her hypothesis that migraine is a metabolic disease. As a result of the success of the first edition of her book and her helping over 5000 migraineurs successfully prevent their migraines world wide, all ages and both genders, and all types of migraines, she published the 2nd (extended) edition of her migraine book "Fighting The Migraine Epidemic: Complete Guide: How To Treat & Prevent Migraines Without Medications". The 2nd edition is the “holy grail” of migraine cause, development, and prevention, incorporating all there is to know. It includes a long section for medical and research professionals. The book is full of academic citations (over 800) to authenticate the statements she makes to make it easy to follow up by those interested and to spark further research interest. It is a "Complete Guide", published on September 29, 2017. Dr. Stanton received her BSc at UCLA in Mathematics, MBA at UCR, MS in Management Science and Engineering at Stanford University, PhD in Economics with dissertation in neuroscience (culminating in Neuroeconomics) at Claremont Graduate University, fMRI certification at Harvard University Medical School at the Martinos Center for Neuroimaging for experimenting with neurotransmitters on human volunteers, certification in LCHF/ketogenic diet from NN (Nutrition Network), certification in physiology (UPEN via Coursea), Nutrition (Harvard Shool of Public Health) and functional medicine studies. Dr. Stanton is an avid sports fan, currently power weight lifting and kickboxing. For relaxation (yeah.. about a half minute each day), she paints and photographs and loves to spend time with her family of husband of 45 years, 2 sons and their wives, and 2 granddaughters. Follow her on Twitter at: @MigraineBook, LinkedIn at and facebook at
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2 Responses to New Journal Article Published on Migraine

  1. Roald Michel says:

    “All 100% of the participants ate a high amount of sweeteners…….” Yuuuuuck!

    Um…. it took the folks of Mental Health in Family Medicine almost 2 months to accept your article. Guess in their world that’s pretty fast, no?

    Are you a member of iMedPub Journals?

    Note: Posted this also in Stanton Migraine Protocol 🙂

    Liked by 1 person

    • Yeah! EVERYONE is a sugar or sugar substitute addict in the US! It is sad but true. So I transformed the group and now those who have been with the group for at least a month are all sweetener free completely and even avoid high carbs fruits and veggies. 🙂 Nice change because so many people had their blood pressure just dropped back to normal after they stopped sugar! They blame hypertension on salt but actually it is sugar. None of us in the group (and that is over 4000 people over the 2 years) had any increase in BP from salt but all who had high BP went to normal (with the exception of 2 who had hypertension for different reasons).

      The journal reviewers fought the paper with tooth and nails. One in particular. But the fight stopped when he/she started to criticize academic journals I cited saying “how dare I suggest that some of these drugs like Topamax cause permanent damage”… for which I sent him/her the FDA label of Topamax.. lol.. on page one it lists the permanent damages it causes. So that was the end of that reviewer! The other reviewer was very nice and I received very helpful constructive criticism and suggestions, all of which I used to improve the paper. But the other reviewer had to get out of the picture to get it published. At one point he/she withdrew or accepted or just gave up… not sure. Two months is actually very short for acceptance. Most articles take 6+ months to be accepted! So in the academic world this was with the speed of light. 😀

      No, I am not member of iMedPub Journals although I suppose now they consider me as one. I am getting articles to review myself… so I suppose I am a member now. No clue. I am not paying membership to be a member. In fact, for now, the only academic membership I retained is to the Society of Neuroscience, and that is an emeritus membership, so free now. That is my favorite association. They are huge and VERY nice. I also introduced my dissertation on one of their San Diego conferences–albeit I managed to get food poisoning the night before so my dissertation chair took over since TV camera crew was about to interview me… and I was throwing up in the hotel room… so much for that. But he did a good job–better than I would have. 🙂

      I post the same answer on Stanton Migraine Protocol as well so folks know what this is about. 🙂


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