Artificial sweeteners, Sugar alcohols, Novel, & Natural non-sugar sweeteners

I have an article to post about aspartame but just so you know, this goes for all sugar substitutes and artificial sugars. According to Mayo Clinic, sugar substitutes are broken down into 4 groups:

  1. Artificial sweeteners (i.e. aspartame),
  2. Sugar alcohols (i.e. Xylitol),
  3. Novel sweeteners (i.e. Stevia), and
  4. Natural sweeteners (that are not sugar)(i.e. honey).

See the table below:

Sugar substitutes

Sugar substitutes

Of all of these, I want to talk about one class in particular: Artificial sweeteners. Artificial sweetener means: not sugar though it tastes sweet. You may recall some of your early history lessons: water and wine kept in led storage containers in ancient Roman and Greek times for a reason: led is sweet. It is not sugar but sure would make an awesome sugar substitute! We do not use it because of its weight obviously and because we have been able to identify it as a major toxin. This shows you a key point: not everything that tastes sweet can safely be used as a sugar substitute for human consumption!

Now let’s take a look at one of the sugar substitutes on the list: Aspartame. Aspartame is in many of our foods and drinks and as of late I even heard that it appeared under a new name in Japan (something cute for kids) but I do not have confirmation of that. Nonetheless I have some acquaintances who suffer from “Aspartame toxicity.” Go ahead and search for “Aspartame Toxicity” in any internet search engine and there is going to be a very high likelihood that 90% of the sites that pop up will call this a hoax toxicity. After all, it does not affect test rats and other non-human mammals, why would it affect humans?

General Mammalian Brains versus Human Brains

Of course we know that rat and other mammalian non-human brains are not as evolved as human brains but we tend not to give that a deeper though at a chemical level. Could that be that in addition to its size and lacking some features, may there be some additional difference between the two types of brains?

As it turns out there are many differences, some of which are evolutionarily very different from what you think, but also different in how the two types of brains metabolize certain energy and chemicals that enter the body. As you know, we have a blood brain barrier that few things can cross. Aspartame is one that does albeit not in the form of Aspartame but as formaldehyde after a few chemical changes that include conversion to methyl alcohol, aspartic acid, phelylalnine and then methanol.

There is a major biochemical problem here. Methyl alcohol is known now, and has been known since 1940, to be metabolized differently by humans from every other animal. (Dr. Woody Monte)

Aspartame is primarily made up of aspartic acid and phenylalanine. The phenylalanine has been synthetically modified to carry a methyl group, which provides the majority of the sweetness. That phenylalanine methyl bond, called a methyl ester, is very weak, which allows the methyl group on the phenylalanine to easily break off and form methanol…humans are the only mammals who are NOT equipped with a protective biological mechanism that breaks down methanol into harmless formic acid. This is why animal testing of aspartame does not fully apply to humans. (Dr. Mercola)

Formaldehyde: Aspartame in the brain!

In the human brain, aspartame becomes formaldehyde, a rather toxic chemical as you very well know if you have ever taken a biology class of dead bugs and organs that are kept floating in formaldehyde to prevent rotting… ‘nough said from what that is!

But what does formaldehyde do in the brain? Well for one thing, it prevents organic changes–hence we use it to preserve dead organic tissue to stay unchanged forever. So a chemical like that will do the same in the human body. It modifies the DNA in the human cells so it cannot change: namely methylation. Formaldehyde turns the protein production of the DNA off. This process may be reversed, according to Dr. Monte, using Ubiquinol (a CoQ10 formulation), and also by optimizing leptin and insulin signaling.

Aspartame or Being Floxed? Can they be treated the same way? 

To optimize leptin and insulin signaling, one has to actually follow the Stanton Migraine ProtocolTM, which is a totally coincidental finding. It is coincidental since the Stanton Migraine ProtocolTM is for migraines. One of the goals of that protocol is to reset the metabolic processes and to keep blood sugar and electrolyte as steady and stable as possible 24/7 no matter what a person eats or drinks. Thus using the Stanton Migraine ProtocolTM in combination with the recommended Ubiquinol may in fact reverse the negative effects of having damaged cellular DNA. This may also work for those who had been floxed! Fluoroquinolone drugs damage the mitochondrial DNA and not the human cellular DNA but it may just work! Try it!

Your comments are welcome as always!


About Angela A Stanton, Ph.D.

Angela A Stanton, PhD, is a Neuroeconomist focusing on chronic pain--migraine in particular--physiology, electrolyte homeostasis, nutrition, and genetics. She lives in Southern California. Her current research is focused on migraine cause, prevention, and treatment without the use of medicine. As a forever migraineur from childhood, her discovery was helped by experimenting on herself. She found the cause of migraine to be at the ionic level, associated with disruption of the electrolyte homeostasis, resulting from genetic variations of all voltage dependent channels, gates, and pumps (chanelopathy) that modulate electrolyte mineral density and voltage in the brain. In addition, insulin and glucose transporters, and several other variants, such as MTHFR variants of B vitamin methylation process and many others are different in the case of a migraineur from the general population. Migraineurs are glucose sensitive (carbohydrate intolerant) and should avoid eating carbs as much as possible. She is working on her hypothesis that migraine is a metabolic disease. As a result of the success of the first edition of her book and her helping over 5000 migraineurs successfully prevent their migraines world wide, all ages and both genders, and all types of migraines, she published the 2nd (extended) edition of her migraine book "Fighting The Migraine Epidemic: Complete Guide: How To Treat & Prevent Migraines Without Medications". The 2nd edition is the “holy grail” of migraine cause, development, and prevention, incorporating all there is to know. It includes a long section for medical and research professionals. The book is full of academic citations (over 800) to authenticate the statements she makes to make it easy to follow up by those interested and to spark further research interest. It is a "Complete Guide", published on September 29, 2017. Dr. Stanton received her BSc at UCLA in Mathematics, MBA at UCR, MS in Management Science and Engineering at Stanford University, PhD in Economics with dissertation in neuroscience (culminating in Neuroeconomics) at Claremont Graduate University, fMRI certification at Harvard University Medical School at the Martinos Center for Neuroimaging for experimenting with neurotransmitters on human volunteers, certification in LCHF/ketogenic diet from NN (Nutrition Network), certification in physiology (UPEN via Coursea), Nutrition (Harvard Shool of Public Health) and functional medicine studies. Dr. Stanton is an avid sports fan, currently power weight lifting and kickboxing. For relaxation (yeah.. about a half minute each day), she paints and photographs and loves to spend time with her family of husband of 45 years, 2 sons and their wives, and 2 granddaughters. Follow her on Twitter at: @MigraineBook, LinkedIn at and facebook at
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16 Responses to Artificial sweeteners, Sugar alcohols, Novel, & Natural non-sugar sweeteners

  1. Roald Michel says:

    Just in: “Diet Pepsi with aspartame returning to shelves in the US less than a year after PepsiCo reformulated the drink with a different artificial sweetener.”

    When will they ever learn? 😡

    Liked by 1 person

  2. Fascinating. I am always interested in what I put into my body. I avoid any type of sweeteners.

    Liked by 1 person

    • Good for you Louise! I do too! 😀 And every member in my migraine group (just under to 2000 at the moment) also does that. It is magic what happens when you remove all poison from your body! You actually get to live, stop all medicines because nothing is hurting, and finally enjoy life–lose a few pounds as well. BP drops, cholesterol drops.. you name it, it is happening! ❤

      Liked by 1 person

      • Thank you for your presence and wisdom. This is an important issue for me. I love chocolate but I haven’t had any for some while. I find the problem is going out to friends, it’s hard to refuse something they give you and you may even like but don’t want to eat it. It’s also really hard to know what is in things that’s why I feed myself simple natural food as much as I can.

        Liked by 1 person

        • I agree Louise! But by now I have come to the conclusion that my health is more important than a piece of chocolate or anything else that may hurt me. I am a migraineur so my presence of mind and remaining pain free is more important than to join my friends in something that I know will cause me a migraine. So I make sure my friends know and if they offer me things I should not have (like sugar) in spite of my telling them that I cannot have any, not sure they are friends… I watch out for my friends and make sure they do NOT eat something that will hurt them and would never ever offer them or eat in front of them something that I know is not possible for them to eat. 🙂 Choose your friends wisely! ❤

          Liked by 1 person

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