Scientific Evidence on Cipro and Similar! In Case You Had Doubts!

One of the commentators to my previous blog post “Those Amazing Antibiotics & How One Class Hurts You” has responded with a very important comment that I think you all should see as a main article. The comment from Debbie T Carol hit a nerve that reinforced the suspicion and substantiated the allegations of all drugs in the class of Cipro (fluoroquinolones) being bad drugs. I decided to copy paste her comment here for you all to read since she has commented with a letter by a doctor who after years of evaluation found a direct connection between fluoroquinolones and very serious adverse reactions and sent it to the Senate for review. This happened earlier this year and things do not happen fast in government, as we know. But they will accelerate if you all refuse to take these drugs and ask for drugs that are not in the class of fluoroquinolones.

After the comment I also give you the names of all the drugs in the fluoroquinolones class so you can print it out and refuse it if prescribed with links to the full drug profile. Here is the comment:

“This is a letter written by Dr Jay Cohen, who has studied adverse reactions to Fluoroquinolones for many years. He sent it to the U.S. Senate earlier this year

Jay S. Cohen M.D. 1337 Camino Del Mar Suite C Del Mar, CA 92014 Phone: 858.345.1760 Fax: 858.509.8944

Fluoroquinolone Toxicity Syndrome: A Letter to the Senate Committee on Health, Education & Labor

May 9, 2014

To: The United States Senate Committee on Health, Education, Labor and Pensions

Re: Fluoroquinolone Toxicity Syndrome (FTS)

Dear Senators:

Serious adverse reactions to fluoroquinolone antibiotics (FQs) have been reported in medical journals and to the FDA since the 1980s. Although the FDA has increased the warnings on these drugs (Levaquin, Cipro, Avelox, Floxin, Norfolk, Factive), my analysis of FDA data shows that reports continue to climb in number. As of February 2014, approximately 45,000 individual cases of fluoroquinolone toxicity have been reported to the FDA. And, as studies have proven, the FDA receives reports of only 1%-5% of the actual numbers of adverse reactions that occur.

I have been following these medications for 16 years and have evaluated in person or by telephone consultation more than 400 people injured by FQs. In 2001, I published an article, Peripheral Neuropathy with Fluoroquinolone Antibiotics, in the Annals of Pharmacotherapy. This article described 45 cases of severe neurological symptoms such as tingling, numbness, burning pain, twitching, and/or severe weakness. Moreover, 93% of the subjects sustained injuries to other vital systems: agitation, impaired cognitive function, intractable insomnia, hallucinations, psychosis, acute manic episode, joint or muscle pain, or tendon rupture. In many cases, toxicities also involved the cardiovascular and gastrointestinal systems, skin, and sight or hearing. Overall, the majority of my subjects experienced toxicity to multiple body systems. Hence my coining the term Fluoroquinolone Toxicity Syndrome.

Of greatest concern, the majority of my cases had lasted more than 1-2 years and were ongoing. These severe, long term reactions occurred in a generally young and healthy population. The average patient age was 42, many of them athletes. In fact, top athletic organizations now warn athletes to avoid treatment with FQs.

Because of the impaired healing seen in severe FTS patients, we have long suspected genetic injury from FQs. These drugs were designed to injure the genetic structure of bacteria and thereby kill them, and they are very efficient in doing so. However, testing was never performed to ensure that FQs did not also injure human DNA. A recent study using high performance liquid chromatography with mass spectrometrography has demonstrated that FQs do indeed injure human DNA. Further study on this must now be undertaken.

There is no doubt that fluoroquinolones are important medications that help many thousands of people each year, but the indiscriminate prescribing of these highly potent, “big gun” antibiotics for everyday minor infections such as sinusitis, sore throats, or bladder infections is unnecessary and medically negligent. Medical authorities have repeatedly denounced the overuse of FQs. In my 40+ years in pharmacovigilance, FQs surpass Vioxx and thalidomide in the degree of permanent harm done.

FDA warnings currently describe many of the adverse effects of FQs. Recently the FDA has finally acknowledged that FQs can cause permanent injury. However, FDA warnings do not adequately describe the FTS syndrome, so doctors do not consider FTS and instead waste valuable time and expense testing for rare neurologic or rheumatologic disorders, meanwhile discounting or dismissing patients who are suffering severely from FTS. The warnings must be improved and the word about FTS must be spread nationally and worldwide. It can start with you. If you still doubt what I have written here, please examine the extensive literature on FQs toxicity beginning with the articles cited below.

Jay S. Cohen M.D. has been a faculty member at the University of California, San Diego, for three decades and has published more than 20 articles on drug safety in leading medical journals. Based on his articles and books, the FDA chose him as the keynote speaker at a FDA conference in 2004. He has debated FDA officials on drug safety strategies at conferences for the American Society for Clinical Pharmacology and Therapeutics and at the Drug Industry Association. His work has been highlighted in major newspapers and magazines including the New York Times, Newsweek and others. During the anthrax scare of 2001, Dr. Cohen’s article on FQs and his appearance on National Public Radio led the CDC to withdraw its recommendation for Cipro for treating anthrax exposure in favor of other, safer antibiotics.

Important Articles on FTS:

Mayo Clinic. Hall MM, Finnoff JT, Smith J. Musculoskeletal complications of fluoroquinolones: Guidelines and precautions for usage in the athletic population. PM & R (Physical Medicine & Rehabilitation) 2011,Feb;3(2):132 142.

Cohen JS. Peripheral Neuropathy with Fluoroquinolone Antibiotics. Annals of Pharmacotherapy 2001, Dec;35(12):1540 47.

Melhus A. Fluoroquinolones and tendon disorders. Expert Opinion on Drug Safety 2005 Mar;4(2):299 309.

Kim GK, Del Rosso JQ. The risk of fluoroquinolone induced tendinopathy and tendon rupture: What does the clinician need to know. Journal of Clinical and Aesthetic 2010, Apr;3(41):49 54.

Williams RJ, Attia E, et al. The effect of ciprofloxacin on tendon, paratendon, and capsular fibroblast metabolism. American Journal of Sports Medicine 2000, Jun;28:364 369.

Kaleagasioglu F, Olcay E. Fluoroquinolone induced tendinopathy: etiology and preventive measures. Tohoku Journal of Experimental Medicine 2012, 226:251-258.

Adikwu E, Brambaifa N. Ciprofloxacin induced chondrotoxicity and tendinopathy. American Journal of Pharmacology and Toxicology 2012, Oct;7:94 100.

Tsai WC, Yang YM. Fluoroquinolone associated tendinopathy. Chang Gung Medical Journal 2011, Sep/Oct;34(5):461-7.

Khaliq Y, Zhanel GG. Musculoskeletal injury associated with fluoroquinolone antibiotics. Clinical Plastic Surgery 2005, 32:495?502

Gürbay A, Gonthier B, Signorini-Allibe N, Barret L, Favier A, Hincal F. Ciprofloxacin induced DNA damage in primary culture of rat astrocytes and protection by Vitamin E. Neurotoxicology 2006 Jan;27(1):6-10.

Corps AN, Harrall RL, Curry VA, et al. Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin1beta in human tendon derived cells. A potential mechanism of fluoroquinolone induced tendinopathy. Arthritis and Rheumatism 2002, Nov;46(11):3034-40.

Pouzaud F, Bernard B K, The M, et al. In vitro disinhibition of fluoroquinolones’ toxicity on tendon cells: involvement of oxidative stress. Journal of Pharmacology And Experimental Therapeutics 2003, Oct;308:402.

Shakibaei M, de Souza P, van Sickle D, Stahlmann R. Biochemical changes in Achilles tendon from juvenile dogs after treatment with ciprofloxacin or feeding a magnesium deficient diet. Archives of Toxicology 2001 Aug;75(6):369-74.

Biundo JJ Jr, Mipro RC Jr, Fahey P. Sports related and other soft tissue injuries, tendinitis, bursitis, and occupation related syndromes. Current Opinion in Rheumatology 1997, Mar;9(2):151-4.
Dr. Cohen is an Associate (Voluntary) Professor of Preventive Medicine and Psychiatry at the University of California, San Diego, one of the top 20 universities in America. His work in the area of preventing medication side effects has been widely published and is recognized nationally. If you would like Dr. Cohen’s input on your EM, he is available for office or telephone consultations. He charges a fee for his time, just as he charges people with other medical conditions who come to his office or consult with him from around the world. For information, contact Leslie at 858-345-1760 or

NOTE TO READERS: The purpose of this E-Letter is solely informational and educational. The information herein should not be considered to be a substitute for the direct medical advice of your doctor, nor is it meant to encourage the diagnosis or treatment of any illness, disease, or other medical problem by laypersons. If you are under a physician’s care for any condition, he or she can advise you whether the information in this E-Letter is suitable for you. Readers should not make any changes in drugs, doses, or any other aspects of their medical treatment unless specifically directed to do so by their own doctors.

If you find this article informative, please tell your friends, family members, colleagues, and doctors about and the free MedicationSense E-Newsletter.”

I have collected from Wikipedia all the drugs listed there that fall into this class (I include the ones for veterinary use as well! Our pets must also be safe). These are generic names followed by several brand names as they differ in some countries. I left the link to each drug intact so you can click and follow to find out more and so you can educate yourself on what not to take. Note that there are still new ones in development! So this list will have to be kept updated!

Wikipedia list of medications in this class:



The second-generation class is sometimes subdivided into “Class 1” and “Class 2”.


Unlike the first- and second-generations, the third-generation is active against streptococci.


Fourth-generation fluoroquinolones act at DNA gyrase and topoisomerase IV. This dual action slows development of resistance.

In development

Veterinary use

The quinolones have been widely used in agriculture, and several agents have veterinary, but not human, applications.

However, the agricultural use of fluoroquinolones in the U.S. has been restricted since 1997, due to concerns over the development of antibiotic resistance.

Updated 9/28/2020

About Angela A Stanton, Ph.D.

Angela A Stanton, PhD, is a Neuroeconomist focusing on chronic pain--migraine in particular--physiology, electrolyte homeostasis, nutrition, and genetics. She lives in Southern California. Her current research is focused on migraine cause, prevention, and treatment without the use of medicine. As a forever migraineur from childhood, her discovery was helped by experimenting on herself. She found the cause of migraine to be at the ionic level, associated with disruption of the electrolyte homeostasis, resulting from genetic variations of all voltage dependent channels, gates, and pumps (chanelopathy) that modulate electrolyte mineral density and voltage in the brain. In addition, insulin and glucose transporters, and several other variants, such as MTHFR variants of B vitamin methylation process and many others are different in the case of a migraineur from the general population. Migraineurs are glucose sensitive (carbohydrate intolerant) and should avoid eating carbs as much as possible. She is working on her hypothesis that migraine is a metabolic disease. As a result of the success of the first edition of her book and her helping over 5000 migraineurs successfully prevent their migraines world wide, all ages and both genders, and all types of migraines, she published the 2nd (extended) edition of her migraine book "Fighting The Migraine Epidemic: Complete Guide: How To Treat & Prevent Migraines Without Medications". The 2nd edition is the “holy grail” of migraine cause, development, and prevention, incorporating all there is to know. It includes a long section for medical and research professionals. The book is full of academic citations (over 800) to authenticate the statements she makes to make it easy to follow up by those interested and to spark further research interest. It is a "Complete Guide", published on September 29, 2017. Dr. Stanton received her BSc at UCLA in Mathematics, MBA at UCR, MS in Management Science and Engineering at Stanford University, PhD in Economics with dissertation in neuroscience (culminating in Neuroeconomics) at Claremont Graduate University, fMRI certification at Harvard University Medical School at the Martinos Center for Neuroimaging for experimenting with neurotransmitters on human volunteers, certification in LCHF/ketogenic diet from NN (Nutrition Network), certification in physiology (UPEN via Coursea), Nutrition (Harvard Shool of Public Health) and functional medicine studies. Dr. Stanton is an avid sports fan, currently power weight lifting and kickboxing. For relaxation (yeah.. about a half minute each day), she paints and photographs and loves to spend time with her family of husband of 45 years, 2 sons and their wives, and 2 granddaughters. Follow her on Twitter at: @MigraineBook, LinkedIn at and facebook at
This entry was posted in Fibromyalgia, Interesting reading, Migraine-Blog, Must Read, This & That, Thoughts and tagged , , , , , , . Bookmark the permalink.

17 Responses to Scientific Evidence on Cipro and Similar! In Case You Had Doubts!

  1. Pingback: Fluoroquinolones & Aneurysm the FDA Warns | Clueless Doctors fail to keep up with the latest science.

  2. Virginia says:

    Thank you so much for writing about this very horrific situation, so very many people have endured.

    Liked by 1 person

  3. crosbyj2014 says:

    In these times, we need to be responsible for our own safety concerning health. The most widely prescribed fluoroquinolones including Cipro, Levaquin and avelox are quickly damaging the health integrity of our nation. It is too late for me, but we can speak the truth about it. You are so right, together we can accomplish great things. Thank you so much for your support.


  4. Roald Michel says:

    Yet another push to never blindly take what the doctor prescribes and always check what he/she wants you to force down your throat.

    Once my lady had a urinary tract infection, and sure enough, her doc prescribed ciprofloxacin. It helped, but now, after having read this article, it’s off our list for good.


    Liked by 1 person

  5. Good2know says:

    Its important to mention that although a generic such as Cipro has the same damaging effects, generics seem to be protected from lawsuits so I plan on avoiding generics –

    Liked by 1 person

    • That is an interesting point you made! I did not think that generics fall under different rules from brand name since the ingredients are the same. I would have thought that if they are pulled from shelves, the generic name of the class of drugs would be pulled since it is not any one drug within but all are known to have the same problem, only Cipro more well known perhaps because it is more often prescribed?


  6. Glori Lundstrom says:

    Thank you! I look forward to the day that these drugs are reserved for use on serious bacterial infections rather than UTI’s and sinus infections. Thank you again!

    Liked by 1 person

  7. Great to see more progress.

    Liked by 1 person

  8. Stephanie McCoin says:

    Thank you so much for your support!

    Liked by 1 person

  9. Ms. A says:

    So wonderful to have your support!

    Liked by 1 person

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